Miranda Kerr: One Child Is Good for Now

"We have the schedule planned out for him," Kerr says. "We make sure he's doing his play dates, he's doing enough reading time, he's doing enough drawing and painting, arts and crafts and also a lot of fun time."

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/h4ZYK2KOyCw/

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ScienceDaily: Living Well News

http://www.sciencedaily.com/news/living_well/ Stories about health and wellness, lifestyle issues and trends, family concerns and other topics about everyday life.en-usWed, 27 Feb 2013 10:29:57 ESTWed, 27 Feb 2013 10:29:57 EST60http://www.sciencedaily.com/images/logosmall.gifhttp://www.sciencedaily.com/news/living_well/ For more science articles, visit ScienceDaily.http://www.sciencedaily.com/releases/2013/02/130227085840.htm Advertisers who put images of female celebrities and models next to their products spark scorn rather than shopping, according to new research.Wed, 27 Feb 2013 08:58:58 ESThttp://www.sciencedaily.com/releases/2013/02/130227085840.htmhttp://www.sciencedaily.com/releases/2013/02/130227085838.htm Pregnant women should avoid taking vitamin D supplements, new research suggests. Substitution appears to raise the risk of children developing a food allergy after birth.Wed, 27 Feb 2013 08:58:58 ESThttp://www.sciencedaily.com/releases/2013/02/130227085838.htmhttp://www.sciencedaily.com/releases/2013/02/130227085706.htm Same-sex cohabitors report worse health than people of the same socioeconomic status who are in heterosexual marriages, according to a new study, which may provide fuel for gay marriage proponents.Wed, 27 Feb 2013 08:57:57 ESThttp://www.sciencedaily.com/releases/2013/02/130227085706.htmhttp://www.sciencedaily.com/releases/2013/02/130226194006.htm A study finds an increased risk of narcolepsy in children and adolescents who received the A/H1N1 2009 influenza vaccine (Pandemrix) during the pandemic in England.Tue, 26 Feb 2013 19:40:40 ESThttp://www.sciencedaily.com/releases/2013/02/130226194006.htmhttp://www.sciencedaily.com/releases/2013/02/130226141235.htm Fingers are one of the first body parts to suffer from the cold and popular fingerless texting gloves can lead to frostbite and in worst cases, amputation, says an expert.Tue, 26 Feb 2013 14:12:12 ESThttp://www.sciencedaily.com/releases/2013/02/130226141235.htmhttp://www.sciencedaily.com/releases/2013/02/130226101259.htm Orthopedic surgeon, spine specialist says excessive leaning head forward and down, while looking at a phone or other mobile device could result in what some people call ?text neck.?Tue, 26 Feb 2013 10:12:12 ESThttp://www.sciencedaily.com/releases/2013/02/130226101259.htmhttp://www.sciencedaily.com/releases/2013/02/130226081155.htm During sleep, our brains store what we have learned during the day a process even more effective in children than in adults, new research shows.Tue, 26 Feb 2013 08:11:11 ESThttp://www.sciencedaily.com/releases/2013/02/130226081155.htmhttp://www.sciencedaily.com/releases/2013/02/130225181536.htm Results of a major study aimed at assessing the efficacy of the Mediterranean diet in the primary prevention of cardiovascular diseases show that such a diet supplemented with extra-virgin olive oil or tree nuts reduces by 30 percent the risk of suffering a cardiovascular death, a myocardial infarction or a stroke.Mon, 25 Feb 2013 18:15:15 ESThttp://www.sciencedaily.com/releases/2013/02/130225181536.htmhttp://www.sciencedaily.com/releases/2013/02/130225162229.htm Giving back through volunteering is good for your heart, even at a young age, according to researchers.Mon, 25 Feb 2013 16:22:22 ESThttp://www.sciencedaily.com/releases/2013/02/130225162229.htmhttp://www.sciencedaily.com/releases/2013/02/130225153046.htm Targeting CPR education in high-risk neighborhoods could increase the number of bystanders giving CPR and decrease deaths from cardiac arrest, according to a new statement.Mon, 25 Feb 2013 15:30:30 ESThttp://www.sciencedaily.com/releases/2013/02/130225153046.htmhttp://www.sciencedaily.com/releases/2013/02/130225153029.htm The idea that boys are better at math and in competitions has persisted for a long time - primarily because of the competition format. A new study shows that competitions that extend beyond a single round result in parity between the sexes.Mon, 25 Feb 2013 15:30:30 ESThttp://www.sciencedaily.com/releases/2013/02/130225153029.htmhttp://www.sciencedaily.com/releases/2013/02/130225131541.htm A newly released international study reveals that the issue of climate change is not a priority for people in the United States and around the world. The surveys showed that when asked to rank priority worries, people were five times more likely to point to the economy over the environment.Mon, 25 Feb 2013 13:15:15 ESThttp://www.sciencedaily.com/releases/2013/02/130225131541.htmhttp://www.sciencedaily.com/releases/2013/02/130225131532.htm People become more politically liberal immediately after practising a spiritual exercise such as meditation, researchers have found.Mon, 25 Feb 2013 13:15:15 ESThttp://www.sciencedaily.com/releases/2013/02/130225131532.htmhttp://www.sciencedaily.com/releases/2013/02/130225122047.htm New research highlights a memory strategy that may help people who suffer from depression in recalling positive day-to-day experiences.Mon, 25 Feb 2013 12:20:20 ESThttp://www.sciencedaily.com/releases/2013/02/130225122047.htmhttp://www.sciencedaily.com/releases/2013/02/130225112320.htm All employees are accountable for something, but very few fully understand exactly what they are accountable for, according to a new study.Mon, 25 Feb 2013 11:23:23 ESThttp://www.sciencedaily.com/releases/2013/02/130225112320.htmhttp://www.sciencedaily.com/releases/2013/02/130225092248.htm A new study suggests troubling perceptions exist when it comes to women involved in disputes at work.Mon, 25 Feb 2013 09:22:22 ESThttp://www.sciencedaily.com/releases/2013/02/130225092248.htmhttp://www.sciencedaily.com/releases/2013/02/130225092246.htm New research shows that most babies who are slow to put on weight in the first nine months of life have caught up to within the normal range by the age of 13, but remain lighter and shorter than many of their peers. There are significant differences in the pattern of "catchup," depending on the infant's age when the slow weight gain occurs.Mon, 25 Feb 2013 09:22:22 ESThttp://www.sciencedaily.com/releases/2013/02/130225092246.htmhttp://www.sciencedaily.com/releases/2013/02/130222083127.htm Parents know that one day they will have to talk to their children about drug use. The hardest part is to decide whether or not talking about ones own drug use will be useful in communicating an antidrug message. Recent research found that children whose parents did not disclose drug use, but delivered a strong antidrug message, were more likely to exhibit antidrug attitudes.Fri, 22 Feb 2013 08:31:31 ESThttp://www.sciencedaily.com/releases/2013/02/130222083127.htmhttp://www.sciencedaily.com/releases/2013/02/130222083125.htm In Jan. 2012, the United States Department of Agriculture passed a series of regulations designed to make school lunches more nutritious, which included requiring schools to increase whole grain offerings and making students select either a fruit or vegetable with their purchased lunch. However, children cannot be forced to eat these healthier lunches. In a new study, researchers determined that small, inexpensive changes to school cafeterias influenced the choice and consumption of healthier foods.Fri, 22 Feb 2013 08:31:31 ESThttp://www.sciencedaily.com/releases/2013/02/130222083125.htmhttp://www.sciencedaily.com/releases/2013/02/130221194241.htm Virologists have discovered a new class of molecular compounds capable of killing the influenza virus. Working on the premise that too much of a good thing can be a killer, the scientists have advanced previous researchers' methods of manipulating an enzyme that is key to how influenza replicates and spreads. The new compounds will lead to a new generation of anti-influenza drugs that the virus' strains can't adapt to, and resist, as easily as they do Tamiflu.Thu, 21 Feb 2013 19:42:42 ESThttp://www.sciencedaily.com/releases/2013/02/130221194241.htmhttp://www.sciencedaily.com/releases/2013/02/130221143946.htm Scientists have found compelling evidence that older adults can eliminate forgetfulness and perform as well as younger adults on memory tests. The cognitive boost comes from a surprising source -- a distraction learning strategy.Thu, 21 Feb 2013 14:39:39 ESThttp://www.sciencedaily.com/releases/2013/02/130221143946.htmhttp://www.sciencedaily.com/releases/2013/02/130221143912.htm Preliminary research findings suggest learning to use Facebook may help give adults older than 65 a cognitive boost. The study shows that seniors who learned to use Facebook saw improvements in their ability to continuously monitor and quickly add or delete the contents of their working memory.Thu, 21 Feb 2013 14:39:39 ESThttp://www.sciencedaily.com/releases/2013/02/130221143912.htmhttp://www.sciencedaily.com/releases/2013/02/130221141604.htm Damage to muscles and the skeleton is the frequent consequence of carrying heavy backpacks and occupational gear on our backs. New research confirms that damage to the nerves that travel through the neck and shoulders is also a serious risk.Thu, 21 Feb 2013 14:16:16 ESThttp://www.sciencedaily.com/releases/2013/02/130221141604.htmhttp://www.sciencedaily.com/releases/2013/02/130221115801.htm New research suggests the growing number of workers who are single and without children have trouble finding the time or energy to participate in non-work interests, just like those with spouses and kids.Thu, 21 Feb 2013 11:58:58 ESThttp://www.sciencedaily.com/releases/2013/02/130221115801.htmhttp://www.sciencedaily.com/releases/2013/02/130221104357.htm Feeling good about spending money on someone else rather than for personal benefit may be a universal response among people in both impoverished countries and rich nations, according to new research.Thu, 21 Feb 2013 10:43:43 ESThttp://www.sciencedaily.com/releases/2013/02/130221104357.htmhttp://www.sciencedaily.com/releases/2013/02/130221104157.htm An increasing number of people die from unintentional home injury, in large part due to accidental drug overdose, according to a new study.Thu, 21 Feb 2013 10:41:41 ESThttp://www.sciencedaily.com/releases/2013/02/130221104157.htmhttp://www.sciencedaily.com/releases/2013/02/130221084618.htm Intense Facebook usage is found to have a positive effect on psychological well-being, according to a new study.?Thu, 21 Feb 2013 08:46:46 ESThttp://www.sciencedaily.com/releases/2013/02/130221084618.htmhttp://www.sciencedaily.com/releases/2013/02/130221084602.htm Researchers have determined normative data for different exercises such as hopping or running. This enables parents and experts to gauge the motor skills of young children for the first time objectively and thus identify abnormalities at an early stage.Thu, 21 Feb 2013 08:46:46 ESThttp://www.sciencedaily.com/releases/2013/02/130221084602.htmhttp://www.sciencedaily.com/releases/2013/02/130220203711.htm Similar to talking about being fat, talking about being old is an important an indicator of body dissatisfaction, shows new research. Body dissatisfaction is known to be correlated with, and predictive of, physical and mental health problems including binge eating, emotional eating, stress, low self-esteem, depression, and use of unhealthy weight control behaviors. High levels of talking about weight and being fat, ?fat talk?, is known to be a good indicator of body dissatisfaction.Wed, 20 Feb 2013 20:37:37 ESThttp://www.sciencedaily.com/releases/2013/02/130220203711.htmhttp://www.sciencedaily.com/releases/2013/02/130220184955.htm Governments around the world should stop squandering resources fighting an "unwinnable war" against illegal drugs, such as cocaine and heroin. Instead, they should use the cash to curb antibiotic misuse, which poses a far more serious threat to human health, claims a leading ethicist.Wed, 20 Feb 2013 18:49:49 ESThttp://www.sciencedaily.com/releases/2013/02/130220184955.htmhttp://www.sciencedaily.com/releases/2013/02/130220184949.htm Mosquitoes are able to ignore the smell of the insect repellent DEET within a few hours of being exposed to it, according to new research.Wed, 20 Feb 2013 18:49:49 ESThttp://www.sciencedaily.com/releases/2013/02/130220184949.htmhttp://www.sciencedaily.com/releases/2013/02/130220163633.htm Gun violence in the United States can be substantially reduced if Congress expands requirements for background checks on retail gun sales to cover firearm transfers between private parties, a new report concludes.Wed, 20 Feb 2013 16:36:36 ESThttp://www.sciencedaily.com/releases/2013/02/130220163633.htmhttp://www.sciencedaily.com/releases/2013/02/130220163629.htm Bullied children grow into adults who are at increased risk of developing anxiety disorders, depression and suicidal thoughts, according to a new study.Wed, 20 Feb 2013 16:36:36 ESThttp://www.sciencedaily.com/releases/2013/02/130220163629.htmhttp://www.sciencedaily.com/releases/2013/02/130220163557.htm Workplace-based programs that include dietary advice coupled with behavioral counseling appear to be a promising approach for men and women with significant weight loss goals, based on the results of a pilot study. Employees enrolled in the intervention arm of a randomized controlled trial lost on average, 18 pounds over a six-month period compared to a two pound weight gain in a control group.Wed, 20 Feb 2013 16:35:35 ESThttp://www.sciencedaily.com/releases/2013/02/130220163557.htmhttp://www.sciencedaily.com/releases/2013/02/130220131744.htm Using your bicycle to commute to work has numerous health and environmental benefits. Yet, the largest Canadian study on cycling injuries suggests cyclists are at risk of injury due to the lack of cycling infrastructure in large urban centers.Wed, 20 Feb 2013 13:17:17 ESThttp://www.sciencedaily.com/releases/2013/02/130220131744.htmhttp://www.sciencedaily.com/releases/2013/02/130220131742.htm Resveratrol, a substance found in red grapes and red wine, may have the potential to protect against hearing and cognitive decline, according to a new study.Wed, 20 Feb 2013 13:17:17 ESThttp://www.sciencedaily.com/releases/2013/02/130220131742.htmhttp://www.sciencedaily.com/releases/2013/02/130220114337.htm In a discovery that could promise a quick fix to the common hangover, a team of engineers has identified a method for speeding up the body's reaction to the consumption of alcohol.Wed, 20 Feb 2013 11:43:43 ESThttp://www.sciencedaily.com/releases/2013/02/130220114337.htmhttp://www.sciencedaily.com/releases/2013/02/130220113859.htm New research shows that people can recover from poor performance when rivals comment on their failures. The research shows that while criticism from team members sends individuals into downward performance spirals, external criticism can be a trigger that boosts performance as people try to prove the outsiders wrong.Wed, 20 Feb 2013 11:38:38 ESThttp://www.sciencedaily.com/releases/2013/02/130220113859.htmhttp://www.sciencedaily.com/releases/2013/02/130220113235.htm A new psychology study suggests the glue that cements the unique relationship between gay men and straight women is honest, unbiased relationship advice.Wed, 20 Feb 2013 11:32:32 ESThttp://www.sciencedaily.com/releases/2013/02/130220113235.htmhttp://www.sciencedaily.com/releases/2013/02/130220084703.htm Days after the initial announcement by the Food Safety Authority of Ireland (FSAI) on the 15th January that horse and pig DNA were found in beef burgers, researchers conducted an online consumer study, as part of the EU-funded project FoodRisC. This study took place before the latest developments about the widespread presence of horsemeat in certain beef products within some European countries.Wed, 20 Feb 2013 08:47:47 ESThttp://www.sciencedaily.com/releases/2013/02/130220084703.htmhttp://www.sciencedaily.com/releases/2013/02/130220084701.htm New research shows that sleep-deprived people select greater portion sizes of energy-dense snacks and meals than they do after one night of normal sleep. Poor sleep habits can therefore affect people?s risk of becoming overweight in the long run.Wed, 20 Feb 2013 08:47:47 ESThttp://www.sciencedaily.com/releases/2013/02/130220084701.htmhttp://www.sciencedaily.com/releases/2013/02/130220084444.htm Bilingual children develop a better working memory ?- which holds, processes and updates information over short periods of time -? than monolingual children, according to new research. The working memory plays a major role in the execution of a wide range of activities, such as mental calculation (since we have to remember numbers and operate with them) or reading comprehension (given that it requires associating the successive concepts in a text).Wed, 20 Feb 2013 08:44:44 ESThttp://www.sciencedaily.com/releases/2013/02/130220084444.htmhttp://www.sciencedaily.com/releases/2013/02/130220084442.htm Small but mighty Xenon flash for mobile phones - great shots in the dark soon to be a reality.Wed, 20 Feb 2013 08:44:44 ESThttp://www.sciencedaily.com/releases/2013/02/130220084442.htmhttp://www.sciencedaily.com/releases/2013/02/130219201523.htm Adding movement to mental rehearsal can improve performance finds a new study. For high jumpers the study shows that dynamic imagery improves the number of successful attempts and the technical performance of jumps The technique of mental rehearsal is used to consolidate performance in many disciplines including music and sport. Motor imagery and physical practice use overlapping neural networks in the brain and the two together can improve performance as well as promoting recovery from injury.Tue, 19 Feb 2013 20:15:15 ESThttp://www.sciencedaily.com/releases/2013/02/130219201523.htmhttp://www.sciencedaily.com/releases/2013/02/130219172159.htm Researchers believe they have discovered a biological marker of dyslexia, a disorder affecting up to one out of 10 children that makes learning to read difficult. The researchers found a systematic relationship between reading ability and the consistency with which the brain encodes sounds. The good news: Response consistency can be improved with auditory training.Tue, 19 Feb 2013 17:21:21 ESThttp://www.sciencedaily.com/releases/2013/02/130219172159.htmhttp://www.sciencedaily.com/releases/2013/02/130219172157.htm Researchers have identified a biological marker in the immune system that -- beginning at about age 22 -- predicts our ability to fight off the common cold. The study found that the length of telomeres -- protective cap-like protein complexes at the ends of chromosomes -- predicts resistance to upper respiratory infections in young and midlife adults.Tue, 19 Feb 2013 17:21:21 ESThttp://www.sciencedaily.com/releases/2013/02/130219172157.htmhttp://www.sciencedaily.com/releases/2013/02/130219161254.htm Would you prefer $120 today or $154 in one year? Your answer may depend on how powerful you feel, according to new research.Tue, 19 Feb 2013 16:12:12 ESThttp://www.sciencedaily.com/releases/2013/02/130219161254.htmhttp://www.sciencedaily.com/releases/2013/02/130219161246.htm Using a grown-up version of the rock-paper-scissors game, cognitive scientists offer a new theory of the group dynamics that arise in situations as varied as cycles of fashion, fluctuations of financial markets, eBay bidding wars and political campaign strategies. "People playing this kind of game subtly influence each other, converging on similar ways of reasoning over time. The natural analogy for the process is to a flock of birds veering in concert."Tue, 19 Feb 2013 16:12:12 ESThttp://www.sciencedaily.com/releases/2013/02/130219161246.htmhttp://www.sciencedaily.com/releases/2013/02/130219141016.htm Some infants raised in poverty exhibit physical traits that make them more vulnerable to poor care-giving, according to new research. The combination of physiological vulnerability and poor care-giving may lead these children to show increased problem behaviors later in childhood.Tue, 19 Feb 2013 14:10:10 ESThttp://www.sciencedaily.com/releases/2013/02/130219141016.htmhttp://www.sciencedaily.com/releases/2013/02/130219140250.htm Scientists have analyzed 60 years of Academy Awards acceptance speeches as part of a research project that focused on gratitude.Tue, 19 Feb 2013 14:02:02 ESThttp://www.sciencedaily.com/releases/2013/02/130219140250.htmhttp://www.sciencedaily.com/releases/2013/02/130219121503.htm Researchers have discovered that decisions about where to live and how to get from home to work happen simultaneously. What's more, your commuting choices depend not only on cost and travel time, but also on who you are and where you live.Tue, 19 Feb 2013 12:15:15 ESThttp://www.sciencedaily.com/releases/2013/02/130219121503.htmhttp://www.sciencedaily.com/releases/2013/02/130219121218.htm Smartphone snapshots could be instantly converted into professional-looking photographs with just the touch of a button, thanks to a new processor chip.Tue, 19 Feb 2013 12:12:12 ESThttp://www.sciencedaily.com/releases/2013/02/130219121218.htmhttp://www.sciencedaily.com/releases/2013/02/130219121212.htm The most frequent turning point in father-daughter relationships is shared activity -- especially sports -- ahead of such pivotal events as when a daughter marries or leaves home, according to a new study.Tue, 19 Feb 2013 12:12:12 ESThttp://www.sciencedaily.com/releases/2013/02/130219121212.htmhttp://www.sciencedaily.com/releases/2013/02/130219121021.htm A new study has established a possible link between high-fat diets and such childhood brain-based conditions as attention deficit hyperactivity disorder (ADHD) and memory-dependent learning disabilities.Tue, 19 Feb 2013 12:10:10 ESThttp://www.sciencedaily.com/releases/2013/02/130219121021.htmhttp://www.sciencedaily.com/releases/2013/02/130219102542.htm A study has gained new insight into domestic dogs' fear responses to noises. The study provides an important insight into dogs' fear of noises, and could improve our understanding of behavioral signs of fear or anxiety.Tue, 19 Feb 2013 10:25:25 ESThttp://www.sciencedaily.com/releases/2013/02/130219102542.htmhttp://www.sciencedaily.com/releases/2013/02/130219102202.htm A new study shows that human thinkers are conscious cognitive misers. Are we intellectually lazy? Yes we are, but we do know when we take the easy way out, according to a new study. Contrary to what psychologists believe, we are aware that we occasionally answer easier questions rather than the more complex ones we were asked, and we are also less confident about our answers when we do.Tue, 19 Feb 2013 10:22:22 ESThttp://www.sciencedaily.com/releases/2013/02/130219102202.htmhttp://www.sciencedaily.com/releases/2013/02/130219102118.htm Most parents carefully select what television programs and movies their children can watch. But a psychologist says educational shows could come with an added lesson that influences a child?s behavior. Children exposed to educational programs were more aggressive in their interactions than those who weren't exposed.Tue, 19 Feb 2013 10:21:21 ESThttp://www.sciencedaily.com/releases/2013/02/130219102118.htmhttp://www.sciencedaily.com/releases/2013/02/130219090649.htm Researchers have studied adults' accuracy in the recognition of the emotion causing babies to cry. Eye movement and the dynamic of the cry play a key role in recognition. It is not easy to know why a newborn cries, especially amongst first-time parents. Although the main reasons are hunger, pain, anger and fear, adults cannot easily recognize which emotion is the cause of the tears.Tue, 19 Feb 2013 09:06:06 ESThttp://www.sciencedaily.com/releases/2013/02/130219090649.htmhttp://www.sciencedaily.com/releases/2013/02/130218201513.htm Maternal nutrition is important to a developing embryo and to the health of the child later in life. Supplementing the diet with specific vitamins is known to increase health of the fetus for example folic acid (vitamin B9) reduces the risk of spina bifida. However not everything an adult might consume is beneficial to a developing baby. New research shows that caffeine is linked to low birth weight babies and that caffeine from coffee in linked to increasing length of pregnancy.Mon, 18 Feb 2013 20:15:15 ESThttp://www.sciencedaily.com/releases/2013/02/130218201513.htmhttp://www.sciencedaily.com/releases/2013/02/130218173217.htm A new study shows that an increase in fat throughout the thigh is predictive of mobility loss in otherwise healthy older adults.Mon, 18 Feb 2013 17:32:32 ESThttp://www.sciencedaily.com/releases/2013/02/130218173217.htm

Source: http://www.sciencedaily.com/rss/living_well.xml

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Electric Wheelchairs And Other Medical Equipment - Legal News

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Source: http://sflalegalnews.com/electric-wheelchairs-and-other-medical-equipment

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Lenovo ThinkPad Tablet 2

The Lenovo ThinkPad Tablet 2 combines touch, all-day battery life, and ThinkPad styling to the Windows 8 Slate tablet market. It's not a bad first effort, but rivals currently have the upper hand. It can be your all-day companion running from meeting to meeting, and you can get work done with the help of accessories when you finally get back to your desk. Taken alone, it's a very good tablet. Unfortunately, other rivals have better battery life, connections to keyboards, and overall differentiating features.

Design and Features
The Tablet 2 looks professional, with a black PolyCarbonate/ABS plastic cover over a magnesium internal frame. The tablet measures about 7 by 10.5 by 0.34 inches (HWD) and weighs a scant 1.21 pounds alone. Add the optional Bluetooth keyboard ($120) and fitted sleeve ($40), and you're talking a 2.63-pound travel weight. One plus that the Tablet 2 has over its rivals is its built-in slot to carry its included stylus. The Wacom-style stylus has a right-click button, but lacks the eraser tip that rivals like the Dell Latitude 10 and Microsoft Surface Pro have. Weighing less than 1.25 pounds and with its built-in stylus holder, it is a very good handheld PC for running around the office park or for a full day of client meetings.

The Tablet 2 has a few ports and switches on its sides: a micro-USB port for charging, a low-power USB 2.0 port, MicroSD and a SIM slot under a shared door, headset jack, volume, power, rotate lock, a docking port, and a mini-HDMI out port. The SIM slot supplies authentication to an optional WWAN radio, which wasn't in our review unit. The docking connector is mainly for the $100 enterprise-level docking station, since the Bluetooth keyboard and stand lacks a docking port.

The Bluetooth keyboard is very comfortable and has a built-in optical TrackPoint and the usual ThinkPad mouse buttons. But there is no room for a palm rest, and the keyboard has no retention mechanism aside from gravity and friction from the slot carved in its surface. This means that the keyboard stand works fine on a tabletop, but if you use the combo on your lap, the Tablet 2 is likely to slide out if you shift your weight during you work session. Both the keyboard and Tablet 2 fit in a tailor-made fitted sleeve, so the combo can work part-time. The Bluetooth keyboard has its own battery for operation, but it doesn't supply auxiliary power like the keyboard docks for the HP Envy X2 or Acer Iconia W510-1422.

The Tablet 2 charges off of its micro-USB port, which is a plus for the road warrior. Most non-iPhone smartphones use micro-USB to charge, so you can get by only carrying a single charger. The Tablet 2 comes with a 2A USB adapter and a USB to micro USB cable, which you can use with your smartphone or tablet. This also makes it more convenient for the multi-device user, since he can charge the Tablet 2 off of a PC with the USB cable as well. Lenovo also sells a $20 USB vehicle charger so you can charge your tablet on the road.

The Tablet 2's regular USB 2.0 port is problematic. It is full-size, so it will work with all sorts of peripherals like printers, keyboards/mice, and USB memory keys. But the USB port only supplies a few watts of power, so it won't run a large-capacity external hard drive. This shortcoming is a large detriment to getting work done if all you have with you are bus-powered external hard drives. The Dell Latitude 10 and most ultrabook-class tablets have full-power USB ports. The Tablet 2 can connect to 2.4GHz and 5GHz 802.11 a/b/g/n Wi-Fi and Bluetooth 4.0 is supported. GPS is included.

The Tablet 2's screen is a 10.1-inch IPS display with a 1,366-by-768 resolution. This means that you can playback 720p HD content natively, but 1080p content will be scaled down. The system's Wacom-style digitizer and stylus back up the five-point touch screen. When the tip of the stylus comes close to the screen, the capacitive touch sensors turn off, so you aren't making marks with your palm when you're actually drawing on the screen with the stylus. The screen is bright, with a wide angle of view from all sides, and an accelerometer makes sure that screen elements point up at all times.

The Tablet 2 comes with an Intel Atom Z2760 processor, 2GB of memory, and a 64GB of flash storage. When we first turned the Tablet 2 on, it came with 33.4 GB of 50GB free. This is a bit less than the "36.8 GB of 52.2GB free" reported by the Editors' Choice Dell Latitude 10. No doubt much of the used space is the recovery partition plus a selection of pre-installed apps. The Tablet 2 came with Lenovo Companion, Skitch Touch, Evernote Touch, Lenovo Support, a Lenovo Settings app, Accuweather, QuickSnip (a clipping/screenshot utility), Amazon Kindle, Skype, rara.com, Intel AppUp, Lenovo Cloud Storage (SugarSync), and Norton Studio (security). Lenovo also included their QuickLaunch app, which replaces the functions of the Windows 7 Start menu. It's not the most heinous use of space, but since Tablet 2's current options for storage are 64GB only, every bit of storage space is precious. You can of course add storage with the microSD slot. The Tablet 2's front webcam is 2MP and the rear is 8MP with a LED flash. The Tablet 2 has a one-year standard warranty.

Performance
The Intel Atom Z2760 processor in the Tablet 2 ensures Windows 8 32-bit compatibility, so the tablet will work with all your enterprise apps and corporate network protocols. It also means that you can use the browser and plug-ins standardized at your business instead of being limited to Internet Explorer (as you would be on a Windows RT system).

However, while the Atom means that the Tablet 2 has 10-hour battery life (10 hours 11 minutes), it also means that it doesn't perform too well on our multimedia benchmark tests. The Tablet 2 was one of the slowest systems we've ever tested on our Handbrake test (13:27 vs. 1:28 on a Core i5 system like the Microsoft Surface Pro). The Tablet 2 also lagged Atom-powered rivals like the Dell Latitude 10 and Acer W510 on the Handbrake test. On day-to-day tasks, the Tablet 2 put in a passable 1,410 point score on PCMark 7. Basically, if you have a need for corporate information retrieval and media playback all day, the Tablet 2 is fine, but if you need to work on graphics creation on a deadline, you're better off with a more powerful system with an Intel Core processor.

The Lenovo ThinkPad Tablet 2 is a decent Windows 8 Slate tablet. It doesn't win any of the performance tests, but is competitive with its Atom-powered rivals. It's a simple work-based tablet that has a good set of ThinkPad accessories that make it a good fit if you're transitioning ThinkPad users to something a lot more portable. However, for the ultimate in battery life, other systems like the Editors' Choice Dell Latitude 10 and keyboard docking tablets like the Acer Iconia Tab W510 are better choices if battery life is paramount. And let's face it, you're looking at an Atom-based tablet because of its combination of Windows 8 Pro compatibility and phenomenal battery life, right?

BENCHMARK TEST RESULTS

COMPARISON TABLE
Compare the Lenovo ThinkPad Tablet 2 with several other laptops and tablets side by side.

More laptop reviews:
??? Lenovo ThinkPad Tablet 2
??? Dell XPS 10
??? Dell Latitude 10
??? MSI GT70 One-609US Dragon Edition
??? Microsoft Surface Windows 8 Pro
?? more

laptop

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Cell sugar concentrations affect hyaluronan production and cancer growth

Public release date: 27-Feb-2013
[ | E-mail | Share ]

Contact: Kirsi Rilla
kirsi.rilla@uef.fi
358-403-553-218
University of Eastern Finland

According to a recent University of Eastern Finland (UEF) study, elevated cell sugar concentrations increase the production of hyaluronan which, in turn, promotes cancer growth. Regulating the production of hyaluronan may be a way to prevent the spreading of cancer.

Hyaluronan is a long, linear carbohydrate polymer present in the human body. It forms a coating on the surface of many cells and plays a key role in fetal development and in the maintenance of normal tissue balance.

Under normal circumstances, hyaluronan promotes tissue healing; however, it can also maintain inflammation and promote the growth of cancer cells. Due to its high water retention capacity, hyaluronan is widely used in cosmetics and also in the medical sector, for example in the treatment of osteoarthritis symptoms and in eye surgery. Hyaluronan injected into the human body for treatment purposes is not associated with cancer risk.

Cells produce hyaluronan with the help of three cell membrane enzymes (HAS1, HAS2 and HAS3), and the production process also needs glucose derivatives.

Hyaluronan synthase 1, i.e. the HAS1 enzyme, is the least well known of the hyaluronan-producing enzymes, and yet its role in cancer malignity seems to be greater than previously thought. Published in Journal of Biological Chemistry, the UEF study showed that HAS1 requires a higher sugar concentration for the production of hyaluronan than HAS2 and HAS3. This finding may be significant for fighting cancer, as cancer cells are known to thrive on blood glucose. Increased glucose levels can lead to increased production of hyaluronan which, in turn, promotes cancer growth. Increased hyaluronan levels have also been found in diabetics with increased blood sugar levels. Diabetics are known to have a higher risk for breast cancer.

HAS1 also plays a significant role in inflammation, because growth factors associated with inflammation mediation, e.g., interleukins, can increase its activeness. This finding constituted part of the doctoral study of Lic. Med. Hanna Siiskonen, which was recently examined at the University of Eastern Finland.

By regulating hyaluronan levels, it may be possible to prevent the progression of cancer and other pathologies. The first clinical trials involving enzymes which break down hyaluronan have been able to slow down the growth and movement of cancer cells and to enhance the effectiveness of cancer drugs.

At the UEF Institute of Biomedicine, the research group of Professor Raija Tammi and Professor Markku Tammi has been studying hyaluronan for 25 years already, and the group's research is internationally renowned. The group focuses on cell biological mechanisms which regulate hyaluronan production. Together with its partners, the group has established a link between increased hyaluronan levels and a negative cancer prognosis in many cancer types, such as breast, prostate, colon, uterine, lung and ovarian cancer.

###

Further information about the research group is available at: http://www.uef.fi/biolaaketiede/ha

For further information, please contact:

Kirsi Rilla, PhD, Docent (Cell Biology)
University of Eastern Finland
School of Medicine, Institute of Biomedicine
Tel. +35840-3553218
email: kirsi.rilla@uef.fi

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 27-Feb-2013
[ | E-mail | Share ]

Contact: Kirsi Rilla
kirsi.rilla@uef.fi
358-403-553-218
University of Eastern Finland

According to a recent University of Eastern Finland (UEF) study, elevated cell sugar concentrations increase the production of hyaluronan which, in turn, promotes cancer growth. Regulating the production of hyaluronan may be a way to prevent the spreading of cancer.

Hyaluronan is a long, linear carbohydrate polymer present in the human body. It forms a coating on the surface of many cells and plays a key role in fetal development and in the maintenance of normal tissue balance.

Under normal circumstances, hyaluronan promotes tissue healing; however, it can also maintain inflammation and promote the growth of cancer cells. Due to its high water retention capacity, hyaluronan is widely used in cosmetics and also in the medical sector, for example in the treatment of osteoarthritis symptoms and in eye surgery. Hyaluronan injected into the human body for treatment purposes is not associated with cancer risk.

Cells produce hyaluronan with the help of three cell membrane enzymes (HAS1, HAS2 and HAS3), and the production process also needs glucose derivatives.

Hyaluronan synthase 1, i.e. the HAS1 enzyme, is the least well known of the hyaluronan-producing enzymes, and yet its role in cancer malignity seems to be greater than previously thought. Published in Journal of Biological Chemistry, the UEF study showed that HAS1 requires a higher sugar concentration for the production of hyaluronan than HAS2 and HAS3. This finding may be significant for fighting cancer, as cancer cells are known to thrive on blood glucose. Increased glucose levels can lead to increased production of hyaluronan which, in turn, promotes cancer growth. Increased hyaluronan levels have also been found in diabetics with increased blood sugar levels. Diabetics are known to have a higher risk for breast cancer.

HAS1 also plays a significant role in inflammation, because growth factors associated with inflammation mediation, e.g., interleukins, can increase its activeness. This finding constituted part of the doctoral study of Lic. Med. Hanna Siiskonen, which was recently examined at the University of Eastern Finland.

By regulating hyaluronan levels, it may be possible to prevent the progression of cancer and other pathologies. The first clinical trials involving enzymes which break down hyaluronan have been able to slow down the growth and movement of cancer cells and to enhance the effectiveness of cancer drugs.

At the UEF Institute of Biomedicine, the research group of Professor Raija Tammi and Professor Markku Tammi has been studying hyaluronan for 25 years already, and the group's research is internationally renowned. The group focuses on cell biological mechanisms which regulate hyaluronan production. Together with its partners, the group has established a link between increased hyaluronan levels and a negative cancer prognosis in many cancer types, such as breast, prostate, colon, uterine, lung and ovarian cancer.

###

Further information about the research group is available at: http://www.uef.fi/biolaaketiede/ha

For further information, please contact:

Kirsi Rilla, PhD, Docent (Cell Biology)
University of Eastern Finland
School of Medicine, Institute of Biomedicine
Tel. +35840-3553218
email: kirsi.rilla@uef.fi

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-02/uoef-csc022713.php

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BP executive testifies at Gulf oil spill trial

Lamar McKay, former president of BP America and current chief executive of BP's Upstream unit, left, leaves Federal Court after testifying in New Orleans, Tuesday, Feb. 26, 2013. McKay, who was president of BP America at the time of the Deepwater Horizon disaster, became the first BP executive to testify at the federal trial intended to identify the causes of BP's Macondo well blowout and assign percentages of blame to the companies involved. (AP Photo/Gerald Herbert)

Lamar McKay, former president of BP America and current chief executive of BP's Upstream unit, left, leaves Federal Court after testifying in New Orleans, Tuesday, Feb. 26, 2013. McKay, who was president of BP America at the time of the Deepwater Horizon disaster, became the first BP executive to testify at the federal trial intended to identify the causes of BP's Macondo well blowout and assign percentages of blame to the companies involved. (AP Photo/Gerald Herbert)

Lamar McKay, former president of BP America and current chief executive of BP's Upstream unit, leaves Federal Court after testifying in New Orleans, Tuesday, Feb. 26, 2013. McKay, who was president of BP America at the time of the Deepwater Horizon disaster, became the first BP executive to testify at the federal trial intended to identify the causes of BP's Macondo well blowout and assign percentages of blame to the companies involved. (AP Photo/Gerald Herbert)

Lamar McKay, former president of BP America and current chief executive of BP's Upstream unit, leaves Federal Court after testifying in New Orleans, Monday, Feb. 25, 2013. McKay, who was president of BP America at the time of the Deepwater Horizon disaster, became the first BP executive to testify at the federal trial intended to identify the causes of BP's Macondo well blowout and assign percentages of blame to the companies involved. (AP Photo/Gerald Herbert)

NEW ORLEANS (AP) ? A ranking BP executive testified Tuesday that the London-based oil giant and its contractors share the responsibility for preventing blowouts like the one that killed 11 workers and spawned the nation's worst offshore oil spill in 2010.

Lamar McKay, who was president of BP America at the time of the Deepwater Horizon disaster, became the first BP executive to testify at a federal trial intended to identify the causes of BP's Macondo well blowout and assign percentages of blame to the companies involved.

Rig owner Transocean and cement contractor Halliburton also are defendants at trial, which opened Monday.

A plaintiffs' attorney pressed McKay to agree with him that BP bore ultimate responsibility for the blowout, but McKay insisted that managing the hazards of deepwater drilling are a "team effort."

"I think that's a shared responsibility, to manage the safety and the risk," said McKay, now chief executive of BP's Upstream unit. "Sometimes contractors manage that risk. Sometimes we do. Most of the time it's a team effort."

McKay also defended BP's internal probe of the spill, which outlined a series of mistakes by rig workers and faulted decisions by other companies but didn't assign any blame to BP's upper-level management.

"I think it was a substantial investigation," McKay said. "I think we've learned what we can from the accident and we're trying to put those things into practice right now."

McKay, whose testimony will resume Wednesday, called the disaster a "tragic accident" resulting from a "risk that was identified."

It wasn't the first time McKay testified under oath about the spill. He appeared before Congress less than a month after the explosion.

U.S. District Judge Carl Barbier is hearing the case without a jury. Barring a settlement, Barbier will decide how much more money BP and other companies owe for their roles in the disaster.

McKay's testimony followed that of an expert witness for people and businesses suing the company. University of California-Berkeley engineering professor Robert Bea testified that BP PLC didn't implement a 2-year-old safety management program on the rig, which exploded on April 20, 2010.

"It's a classic failure of management and leadership in BP," said Bea, a former BP consultant who also investigated the 1989 Exxon Valdez spill and New Orleans levee breaches after Hurricane Katrina in 2005.

BP has said its "Operating Management System" was designed to drive a rigorous and systematic approach to safety and risk management. During cross-examination by a BP lawyer, Bea said the company made "significant efforts" to improve safety management as early as 2003.

However, the plaintiffs say BP only implemented its new safety plan at just one of the seven rigs the company owned or leased in the Gulf at the time of the disaster.

Bea said it was "tragic" and "egregious" that BP didn't apply its own safety program to the Deepwater Horizon before the Macondo well blowout. Transocean owned the rig; BP leased it.

BP lawyer Mike Brock said the company allows contractors like Transocean to take the primary responsibility for the safety of rig operations as long as the contractor's safety system is compatible with BP's ? an arrangement that Brock suggested is a standard industry practice.

In his May 2010 congressional testimony, McKay said BP's Operating Management System is "as good as anyone."

"I know of nothing that points me in a direction that we have deficiencies" in the system, McKay said.

As he questioned Bea, Brock recited a long list of steps that BP took to improve safety, citing them as evidence that the company wasn't "cutting corners" on safety.

A plaintiffs' lawyer showed Bea a transcript of a deposition of Tony Hayward, BP's CEO at the time of the disaster. Hayward was asked if the blowout could have been averted if BP had implemented the safety management program in the Gulf.

"There is possible potential," Hayward responded. "Undoubtedly."

Bea said BP's "culture of every dollar counts" was reflected in a May 2009 email sent by BP well team leader John Guide: "The DW Horizon embraced every dollar matters since I arrived 18 months ago," Guide wrote. "We have saved BP millions and no one had to tell us."

"Financially, BP had the resources to effectively put into place a process safety system that could have prevented the Macondo disaster," Bea testified.

BP has already pleaded guilty to manslaughter and other criminal charges and has racked up more than $24 billion in spill-related expenses, including cleanup costs, compensation for businesses and individuals, and $4 billion in criminal penalties.

Plaintiffs' attorney Robert Cunningham read portions of the plea agreement as he pressed McKay to say how much responsibility BP takes for the catastrophe. Cunningham noted that nothing in the document assigns blame to specific BP executives.

"That is not written in there. That's true," McKay said.

Two BP rig supervisors, however, have been indicted on manslaughter charges for the workers' deaths and are awaiting a separate trial.

"There were some misinterpretations and mistakes made" on the rig, McKay said.

One of the biggest questions facing Barbier is whether BP acted with gross negligence.

Under the Clean Water Act, a polluter can be forced to pay a minimum of $1,100 per barrel of spilled oil; the fines nearly quadruple to about $4,300 a barrel for companies found grossly negligent, meaning BP could be on the hook for nearly $18 billion.

___

Follow Kunzelman at https://twitter.com/Kunzelman75

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-02-26-Gulf%20Oil%20Spill-Trial/id-90308b2bacf24ccdac5979bc3fb3928a

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BBC: World service frequencies jammed in China

LONDON (AP) ? The BBC says it has received reports that its world service English shortwave radio frequencies are being jammed in China and condemns what it called efforts to disrupt free access to news and information.

The broadcaster said while it can't attribute the source of the jamming definitively, "the extensive and coordinated efforts are indicative of a well-resourced country such as China."

The jamming of broadcasts in China is being timed to cause "maximum disruption," the BBC's director of global news, Peter Horrocks, said in a statement Monday.

In the past, BBC Persian transmissions in Iran have been affected by jamming. Jamming frequencies was also a tactic used by communist nations to block BBC broadcasts during the Cold War.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-02-25-Britain-BBC-China/id-8b03a08ca2e045a5aca8b42b78149a0d

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Study revises colorectal cancer risk down and other cancer risks up for women with Lynch Syndrome

Public release date: 26-Feb-2013
[ | E-mail | Share ]

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

50-60 percent colorectal cancer risk, 11 percent breast, 11 kidney, 9 percent bladder

Lynch Syndrome is a heritable genetic mutation that causes colorectal, endometrial and other cancers. A cooperative study that included the University of Colorado Cancer Center, published in this month's issue of the Journal of the National Cancer Institute, revises the risk of colorectal cancer down but other cancers up for women with Lynch Syndrome who have had endometrial cancer.

"This new information helps patient care in two important ways. First, it helps us counsel women with Lynch Syndrome who have had endometrial cancer about the magnitude of their future cancer risk, which turns out to be about 55 percent over the 20 years after diagnosis of their endometrial cancer. Second, it helps fill in the picture of the spectrum of cancers that are associated with Lynch Syndrome, which includes not only colorectal and endometrial cancers, but kidney, ureter, renal, pelvic, urinary, bladder and breast cancers in that order as well," says Dennis J. Ahnen, MD, CU Cancer Center investigator and professor of gastroenterology at the Denver VA Medical Center, one of the paper's co-authors.

The research group, which includes member from six centers, used data from 127 women included in the Colon Cancer Family Registry (CCFR). Ahnen notes that the CCFR is unique among cancer registries in that it not only collects information on patients with colorectal cancer and their treatment outcomes, but also routinely performs molecular characterization of these tumors, which can show which of these cancers are associated with Lynch Syndrome or other genetic abnormalities. Importantly, this molecular categorization allows researchers to discover which of the three possible pathways led to a patient's cancer the traditional chromosomal instability pathway accounts for about 80 percent of all colorectal cancers, and Lynch Syndrome combines with an epigenetic pathway to account for the remaining 20 percent.

"Knowing a cancer's genetic makeup allows us to ask questions not only about colorectal cancer in general, but about its molecular subtypes separately. These three types are included under the umbrella of colorectal cancer but have different prognoses and react differently to therapies. Effectively, they're quite different diseases," Ahnen says.

One of the study's important findings was an 11 percent lifetime risk for breast cancer after Lynch-associated endometrial cancer, 2.51 times the risk of women outside this population. Also elevated with Lynch Syndrome were lifetime risks of bladder (9 percent) and kidney (11 percent) cancers. But while the current study expands the spectrum of cancers associated with Lynch Syndrome, it also provides estimates of risk of colorectal cancer that are lower than previous estimates.

"When you think about it," Ahnen says, "most of the prior data on Lynch-associated colorectal cancer risk was from people referred to a high-risk clinic usually because of a strong family history of cancer. Of course, these people are likely to have higher cancer risk than the general population. The registry data minimizes this selection bias and allows us to look at a more representative cross-section of the colorectal cancer population. This cross-section shows a 50-60 percent lifetime risk of developing colorectal cancer in people with Lynch Syndrome, as opposed to earlier estimates of 70-80 percent risk."

"There are many remaining questions we can ask using the CCFR data," Ahnen says. "For example, what's the best way to screen people for Lynch Syndrome? Based on the risks the registry shows, should we screen all colorectal cancers for Lynch and then all family members of Lynch patients for the mutation or should we focus on some clinical subset of the population such as those with CRC at a young age? Likewise we can determine if colorectal cancers that arise from different molecular pathways are associated with different risk factor profiles, different prognoses or have different responses to available treatments."

To Ahnen, this specific study's findings are important but even more essential is the approach taken by the Colon Cancer Family Registry to collect and molecularly characterize these cancers. As cancer becomes an ever-longer list of related but distinctly different diseases, each perhaps with a molecular Achilles heel, the Colon Cancer Family Registry allows researchers like Ahnen to ask questions about treatment of these molecular subtypes that are rarely possible with cancer registries that treat, say, breast or prostate cancers as monolithic diseases.

Cancer is becoming seen as "cancers" and in many ways, the Colon Cancer Family Registry allows researchers in this field to lead the way.

###

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 26-Feb-2013
[ | E-mail | Share ]

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

50-60 percent colorectal cancer risk, 11 percent breast, 11 kidney, 9 percent bladder

Lynch Syndrome is a heritable genetic mutation that causes colorectal, endometrial and other cancers. A cooperative study that included the University of Colorado Cancer Center, published in this month's issue of the Journal of the National Cancer Institute, revises the risk of colorectal cancer down but other cancers up for women with Lynch Syndrome who have had endometrial cancer.

"This new information helps patient care in two important ways. First, it helps us counsel women with Lynch Syndrome who have had endometrial cancer about the magnitude of their future cancer risk, which turns out to be about 55 percent over the 20 years after diagnosis of their endometrial cancer. Second, it helps fill in the picture of the spectrum of cancers that are associated with Lynch Syndrome, which includes not only colorectal and endometrial cancers, but kidney, ureter, renal, pelvic, urinary, bladder and breast cancers in that order as well," says Dennis J. Ahnen, MD, CU Cancer Center investigator and professor of gastroenterology at the Denver VA Medical Center, one of the paper's co-authors.

The research group, which includes member from six centers, used data from 127 women included in the Colon Cancer Family Registry (CCFR). Ahnen notes that the CCFR is unique among cancer registries in that it not only collects information on patients with colorectal cancer and their treatment outcomes, but also routinely performs molecular characterization of these tumors, which can show which of these cancers are associated with Lynch Syndrome or other genetic abnormalities. Importantly, this molecular categorization allows researchers to discover which of the three possible pathways led to a patient's cancer the traditional chromosomal instability pathway accounts for about 80 percent of all colorectal cancers, and Lynch Syndrome combines with an epigenetic pathway to account for the remaining 20 percent.

"Knowing a cancer's genetic makeup allows us to ask questions not only about colorectal cancer in general, but about its molecular subtypes separately. These three types are included under the umbrella of colorectal cancer but have different prognoses and react differently to therapies. Effectively, they're quite different diseases," Ahnen says.

One of the study's important findings was an 11 percent lifetime risk for breast cancer after Lynch-associated endometrial cancer, 2.51 times the risk of women outside this population. Also elevated with Lynch Syndrome were lifetime risks of bladder (9 percent) and kidney (11 percent) cancers. But while the current study expands the spectrum of cancers associated with Lynch Syndrome, it also provides estimates of risk of colorectal cancer that are lower than previous estimates.

"When you think about it," Ahnen says, "most of the prior data on Lynch-associated colorectal cancer risk was from people referred to a high-risk clinic usually because of a strong family history of cancer. Of course, these people are likely to have higher cancer risk than the general population. The registry data minimizes this selection bias and allows us to look at a more representative cross-section of the colorectal cancer population. This cross-section shows a 50-60 percent lifetime risk of developing colorectal cancer in people with Lynch Syndrome, as opposed to earlier estimates of 70-80 percent risk."

"There are many remaining questions we can ask using the CCFR data," Ahnen says. "For example, what's the best way to screen people for Lynch Syndrome? Based on the risks the registry shows, should we screen all colorectal cancers for Lynch and then all family members of Lynch patients for the mutation or should we focus on some clinical subset of the population such as those with CRC at a young age? Likewise we can determine if colorectal cancers that arise from different molecular pathways are associated with different risk factor profiles, different prognoses or have different responses to available treatments."

To Ahnen, this specific study's findings are important but even more essential is the approach taken by the Colon Cancer Family Registry to collect and molecularly characterize these cancers. As cancer becomes an ever-longer list of related but distinctly different diseases, each perhaps with a molecular Achilles heel, the Colon Cancer Family Registry allows researchers like Ahnen to ask questions about treatment of these molecular subtypes that are rarely possible with cancer registries that treat, say, breast or prostate cancers as monolithic diseases.

Cancer is becoming seen as "cancers" and in many ways, the Colon Cancer Family Registry allows researchers in this field to lead the way.

###

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-02/uocd-src022613.php

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Billboard turns desert air into pure water

John Roach , NBC News ? ? ? 6 hrs.

Billboards provide parched drivers cruising down the highway in Lima, Peru with ample ideas for ways to quench their thirst, from soda to beer, but only one turns the desert air to drinkable water right there.

The billboard is a marketing campaign created by ad agency Mayo DraftFCB intended to inspire would-be engineers to apply for admission to the University of Engineering and Technology.

Lima is located in a desert and receives less than an inch of rain a year, causing many residents to rely on polluted wells for their drinking water. But the coastal city also experiences high levels of humidity ? about 98 percent, which got the ad agency and the university thinking about the billboard.

The working billboard houses generators that capture humidity and send it through a reverse osmosis system to generate water, a video about the project (above) from the ad agency explains. The water is filtered and stored in tanks. A tap at the base supplies water to local residents.

The billboard can generate up to 25 gallons of water a day. Time will tell how many students it inspires to apply to school, gain engineering skills and change the world.

? via Discovery News, PSFK

John Roach is a contributing writer for NBC News. To learn more about him, check out his website. For more of our Future of Technology series, watch the featured video below.

Source: http://www.nbcnews.com/technology/futureoftech/billboard-turns-desert-air-pure-water-1C8543843

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Fragments of continents hidden under lava in Indian Ocean: New micro-continent detected under Reunion and Mauritius

Feb. 22, 2013 ? The islands Reunion and Mauritius, both well-known tourist destinations, are hiding a micro-continent, which has now been discovered. The continent fragment known as Mauritia detached about 60 million years ago while Madagascar and India drifted apart, and had been hidden under huge masses of lava.

Such micro-continents in the oceans seem to occur more frequently than previously thought, says a study in the latest issue of Nature Geoscience.

The break-up of continents is often associated with mantle plumes: These giant bubbles of hot rock rise from the deep mantle and soften the tectonic plates from below, until the plates break apart at the hotspots. This is how Eastern Gondwana broke apart about 170 million years ago. At first, one part was separated, which in turn fragmented into Madagascar, India, Australia and Antarctica, which then migrated to their present position.

Plumes currently situated underneath the islands Marion and Reunion appear to have played a role in the emergence of the Indian Ocean. If the zone of the rupture lies at the edge of a land mass (in this case Madagascar / India), fragments of this land mass may be separated off. The Seychelles are a well-known example of such a continental fragment.

A group of geoscientists from Norway, South Africa, Britain and Germany have now published a study that suggests, based on the study of lava sand grains from the beach of Mauritius, the existence of further fragments. The sand grains contain semi-precious zircons aged between 660 and 1970 million years, which is explained by the fact that the zircons were carried by the lava as it pushed through subjacent continental crust of this age.

This dating method was supplemented by a recalculation of plate tectonics, which explains exactly how and where the fragments ended up in the Indian Ocean. Dr. Bernhard Steinberger of the GFZ German Research Centre for Geosciences and Dr. Pavel Doubrovine of Oslo University calculated the hotspot trail: "On the one hand, it shows the position of the plates relative to the two hotspots at the time of the rupture, which points towards a causal relation," says Steinberger. "On the other hand, we were able to show that the continent fragments continued to wander almost exactly over the Reunion plume, which explains how they were covered by volcanic rock." So what was previously interpreted only as the trail of the Reunion hotspot, are continental fragments which were previously not recognized as such because they were covered by the volcanic rocks of the Reunion plume. It therefore appears that such micro-continents in the ocean occur more frequently than previously thought.

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The above story is reprinted from materials provided by Helmholtz Centre Potsdam - GFZ German Research Centre for Geosciences.

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Journal Reference:

1. Trond H. Torsvik, Hans Amundsen, Ebbe H. Hartz, Fernando Corfu, Nick Kusznir, Carmen Gaina, Pavel V. Doubrovine, Bernhard Steinberger, Lewis D. Ashwal, Bj?rn Jamtveit. A Precambrian microcontinent in the Indian Ocean. Nature Geoscience, 2013; DOI: 10.1038/NGEO1736

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/OaIWm9jLxY4/130224142725.htm

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